Slamet Raharjo, - and Adi Pranoto, - and Purwo Sri Rejeki, - and A.S.M. Harisman, - and Yualita Putri Pamungkas, - and Olivia Andiana, - (2021) Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity. Open Access Macedonian Journal of Medical Sciences, 9 (B). pp. 1021-1026. ISSN 1857-9655

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Abstract

BACKGROUND: Obesity has been widely associated with structural and functional changes in the brain, whereas inflammation is one of the potential mechanisms involved in these changes. OBJECTIVE: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index and waist to hip ratio) and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity. METHODS: This study used a cross-sectional study method using 33 females with obesity aged 19-23 years, body mass index (BMI) > 27.5 kg/m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb), and fasting blood glucose (FBG) ≤ 100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were analyzed using Pearson product-moment test with a significant levels p<0.05. RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p<0.001), WHR (r = –0.675; p<0.001), IL-6 levels (r = –0.530; p<0.001) and TNF-α levels (r = –0.561; p<0.001). CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, waist to hip ratio, and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity. Further studies are needed to confirm the present findings.

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