David Setyo Budi, - and Reny I'tishom, - and Alphania Rahniayu, - and Mohammad Fathul Qorib, - (2020) The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure. Indian Journal Forensic Medicine & Toxicology, 14 (4). pp. 2201-2206. ISSN 0973-9122

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Abstract

Background: Disruption to healing process results on longer healing duration from the timeline. Povidone iodine and tulle are common management in wound care. The advance of industry in health sector and the availability of natural ingredients in Indonesia provide opportunities for developing alternatives for wound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial, and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan can maintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potential of turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with “post-test only control group design”. The sample consisted of 30 mice which were assigned into 5 groups. Result: All experimental groups experienced a gradual decrease in wound length. The statistical test results for groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group I did not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but it had significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate the reduction of wound length.

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