Abadiyah Zakiyah Kustantina, - and Reny I'tishom, - and Siti Khaerunnisa, - (2020) Pengaruh Variasi Dosis Ekstrak Terong Belanda Terhadap Konsentrasi Spermatozoa Pada Mus MuscullusYang Dipapar Timbal Asetat. Jurnal Penelitian Kesehatan Suara Forikes, 11. pp. 100-104. ISSN 2086-3098

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Abstract

Infertility is a 10-15% problem experienced by men around the world. One of the causes of infertility in men is caused by an increase in reactive oxygen species (ROS) by toxic substances such as heavy metal lead (Pb). This research was conducted to find the potential of Dutch eggplant fruit (Solanum betaceum) in various doses to increase the concentration of mice spermatozoa (Mus muscullus) exposed to lead acetate. Dutch eggplant has a good phenolic content as an antioxidant to prevent free radicals. The study design used was Posttest only control group design with a sample of 40 male mice. The treatment time in all groups is 35 days. Mice were divided into 5 groups that were given oral treatment. The control group was given 75 mg/kgBWof lead acetate treatment. The treatment group was given lead acetate 75mg / KgBB and Dutch eggplant extract at various doses of 100mg/kgBW(P1), 200mg/kgBW(P2), and 400mg/kgBW(P3). The results showed that Dutch eggplant extract (Solanum betaceum) with various doses could significantly increase spermatozoa concentration. The optimal dose of Dutch eggplant extract (Solanum betaceum) inmice exposed to lead is 100 mg/kg/day in the treatment group (P1).

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