Maria S Ganggur, - and Sony Wibisono, - and Musofa Rusli, - (2020) Correlation between Serum Cortisol Levels and Cd4 Counts in Treatment-Native Patients with HIV/AIDS Infection at Tertiary Hospital. Systematic Reviewes in Pharmacy, 11 (3). pp. 596-602. ISSN 0975-8453

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Abstract

The increased cortisol is significantly correlated with HIV mortality. The objective of this study was to analyze the correlation between serum cortisol levels and CD4 counts in treatment-naïve patients with HIV/AIDS infection. This was an analytical cross-sectional study. Total serum cortisol levels were measured by ADVIA Centaur® using chemiluminescence immunoassay and CD4 counts were measured by flow cytometry technique using BD FACS Count CD4 reagants®. Among 56 samples of treatment-naïve patients with HIV/AIDS infection, the mean age was 34.3 ± 9 years and they were predominantly male. Mean total cortisol levels was 18.88 ± 9.90 µg/dL, and 32.1% of samples had total cortisol levels of >22.4 µg/dL. As much as 67.9% of the samples presented CD4 counts lower than 200 cells/mm3. There was a significant moderate negative correlation between total cortisol levels and CD4 counts (r = -0.467, p<0.001).Total cortisol levels were negatively correlated with CD4 counts. The higher the total cortisol levels of HIV/AIDS-positive patients, the lower the CD4 counts.

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