Rosa Sharon Suhono (2010) Pengaruh Feeding Ekstrak Kedelai Terhadap Pertambahan Jumlah Sel Osteoblas Tulang Alveolar Pasca Pencabutan Gigi (Penelitian Eksperimental Laboratoris Pada Tikus Jenis Wistar). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background. Many researchs were done to found some natural materials that may increase and promote bone remodelling in order to improve treatment of osteoporosis, and bone healing proccess after trauma and surgery. One of natural material that had been studied was soybean extract that contained phytoestrogen, a non-steroidal compounds found in plants that may binds to estrogen receptors and have estrogen-like activity. Purpose. The aim of this study was to investigate the effect of soybean extract foeding on the number of osteoblast in alveolar bone after mandibular tooth extraction histopathologically. Method. This study was studied on male Rattus Norvegicus strain wistar. Seventeen rats which were divided into three groups, were used in this study. The sample groups received different treatment: (Group 1) Fed with CMC(Carboxy Methyl Cellulose) solution 0,2% for seven days, and a mandibular central incisivus was extracted, (Group 2) Fed with soybean extract for seven days, and then a mandibular central incisivus was extracted, (Group 3) Group that received mandibular central incisivus extraction, followed by soybean extract foeding for seven days after the extraction. All groups were sacrificed on the seventh day after extraction, and the socket was removed for histopathological observation. The tissues were processed and Hematoxylin & Eosin stained were used, to identified the amount of osteoblast. The number of osteoblast was counted using Image Tool program. The data was analized with Anova One-way test. Results. Significant difforences were found on the number of osteoblast in alveolar bone after tooth extraction between groups that fed with soybean extract and group that found in control groups. Conclusion. Histopathological observation on post-extracted socket in rats showed that soybean extract feeding significantly increase the number of osteoblast in post-extracted socket in rats, in groups received soybean extract feedingfor seven days before and after tooth extraction

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