Is Effendi, Wiwin and Nagano, Tatsuya and Hasan, Helmia and Yudhawati, Resti (2020) Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases. International Journal of Molecular Sciences, 21 (10). ISSN 1422-0067
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Abstract
The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD) remains poorly understood. Immunoreceptor tyrosine-based motif-bearing C-type lectin-like receptors (CTLRs) may interact with various immune cells during tissue injury and wound repair processes. Dectin-1 is a CTLR with dominant mechanisms manifested through its intracellular signaling cascades, which regulate fibrosis-promoting properties through gene transcription and cytokine activation. Additionally, immune impairment in ILD facilitates microbiome colonization; hence, Dectin-1 is the master protector in host pulmonary defense against fungal invasion. Recent progress in determining the signaling pathways that control the balance of fibrosis has implicated immunoreceptor tyrosine-based motif-bearing CTLRs as being involved, either directly or indirectly, in the pathogenesis of fibrosing ILD. Keywords: innate immunity, pattern recognition receptors, C-type lectin-like receptors, immunoregulatory receptor, tyrosine-based signaling motifs, interstitial lung diseases
Item Type: | Article | ||||||||||
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Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) | ||||||||||
Divisions: | 01. Fakultas Kedokteran > Ilmu Pulmonologi dan Ilmu kedokteran Respirasi | ||||||||||
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Depositing User: | arys fk | ||||||||||
Date Deposited: | 08 Nov 2022 01:05 | ||||||||||
Last Modified: | 03 Apr 2023 05:47 | ||||||||||
URI: | http://repository.unair.ac.id/id/eprint/118527 | ||||||||||
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