Sri Ratna Dwiningsih, - and Budi Santoso, - (2009) Perbandingan kadar sex hormone bindling globulin (shbg) dan kejadian ovulasi pada pemberian metformin selama 2 minggu (terhadap wanita sindroma ovarium polikistik yang mendapat terapi klomifen sitrat). Majalah Obstetri & Ginekologi, 17 (2). pp. 67-70. ISSN 0854-0381

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Abstract

The objective of this study was to determine if short courses of metformin administration in patients with polycystic ovary syndrome (PCOS) would reduce insulin resistant and improve the efficacy of clomiphene citrate 9CC) to induce ovulation. This study was using a randomizes prospective trial ainvolving 33 subjects with PCOS and infertility. The setting of this study was infertility outpatient clinic Dr. Seotomo Hospital Surabaya from July 2007 until January 2008. The samples of this study were oatients with PCOS wew treated either with CC + metformin increase significant than group CC (p=0.003); 79% of subjects ovulating in the CC + metformin group compare 46% CC group (p=0.008). One subject in group CC + metformin conceived. The conclusion is 2 weeks administered metformin could reduce insulin resistance; it would impact on increase SHBG level and improve the efficacy of CC to induction.

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