Muhammad Ikhsan, Muhammad and Iswinarno Doso Saputro, Iswinarno and M. Sjaifuddin Noer, M. Sjaifuddin The Role of the Bovine Amniotic Membrane in Accelerating of Wound Epithelization: A Systematic Review and Meta-analysis. Annals of The Romanian Society for Cell Biology, 25 (6). ISSN 1583-6258

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Abstract

ABSTRACT Modern dressings promise a smoother and less visible scar than typical wound management. The bovine amniotic membrane, one of the amniotic membranes that is often to be used in wound management known to be safe and effective in accelerating wound healing. However, no robust data of its effect in accelerating wound healing is available. The aim of this systematic-review and meta￾analysis was to provide robust data on the role of bovine amniotic membrane on wound epithelization process. The searches of the eligible studies were conducted in two databases (Medline and PubMed). Data on authors, year of publication, location, type of wound dressing, and the outcomes were collected from each eligible study based on PRISMA guideline. Five studies from the systematic review, included human and non-human wounds, were included in the meta-analysis and all of them used freeze-dried bovine amniotic membrane. Individual study found indicated that freeze-dried bovine amniotic membrane could accelerate epithelialization in wound healing. However, meta￾analysis suggested that there was no difference between administration of freeze-dried bovine amniotic membrane and the use of other dressing in term of epithelialization process on wound healing (summary of effect was 69.52and 95% confidence interval (95%CI) from -61 to 200). In conclusion, there areno adequate data and therefore there is no strong evidence from human and non￾human wounds to suggest that bovine amniotic membrane accelerates the wound epithelization faster than other types of dressing. Keywords: Wound healing, bovine amniotic membrane, epithelialization

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