M. Yulianto Listiawan and Flora Ramona Sigit Prakoeswa, - and Anang Endaryanto, - and Cita Rosita Sigit Prakoeswa, - (2021) Correlation of Hematological Parameters on Maternal and Pediatric Leprosy ImmunityRatio: A Study in Endemic Areas in East Java, Indonesia. Indian Journal of Forensic Medicine & Toxicology, 15 (3). pp. 3767-3771. ISSN 09739130

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Abstract

Background: Leprosy is chronic infectious disease caused by Mycobacterium leprae. Endemic areas still existed with stable number of new cases including new cases of pediatric leprosy and female leprosy cases. Close contact and women’s role in household increase the risk of transmission of leprosy to their children. Population lived in endemic areas are prone to contract leprosy due to dysregulation of immune system. This study aims to analyze correlation of hematological parameters and immunity ration in maternal and pediatric leprosy in endemic areas. Methods: This is a cross-sectional study in endemic areas in Tuban Regency, East Java Province, Indonesia. The blood sample was taken from the subjects and underwent complete hematological parameter test (hemoglobin, red blood cells, white blood cells, platelets, hematocrit) and measurement of T cells activityratio(Th1/Th2 ratio and Th17/Treg ratio) by ELISA. Correlation test was done between blood test resultsand the immunity ratio of maternal and pediatric leprosy in endemic areas. Results: 33 pairs of maternal and pediatric leprosy cases were analyzed. This study found correlation between RBC (p value= 0.029) and HCT (p value= 0.038) with Th17/Treg ratio in children population. No significant results observed in mothers population. Conclusion: The result of this study shows that hematological paramaters (HB and HCT) related to the Th17/Treg ratio and could play roles in the incidence of dysregulation of immune system in children leprosy.

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