Expression of Melan-A in Depigmented Skin of Vitiligo Patients

Tjokorde Istri Nindya Vaniary, - and M. Yulianto Listiawan and Dwi Murtiastutik, - (2020) Expression of Melan-A in Depigmented Skin of Vitiligo Patients. Berkala Ilmu Kesehatan Kulit dan Kelamin – Periodical of Dermatology and Venereology, 32 (1). pp. 17-20. ISSN 2414-6366

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Official URL: https://e-journal.unair.ac.id/BIKK/article/view/12...

Abstract

Background: Vitiligo is an acquired and commonly found pigmentation disorder characterized by milky-white patches on the skin, hair, and mucosa due to melanocyte damage. The cause of vitiligo is still unclear. A study proves that cell-mediated immunity plays a role in the pathogenesis of vitiligo. Melan-A is a melanoma-related antigen that is recognized by autologous cytotoxic T cells and one of the critical markers for detecting melanocytes. Objective: To evaluate the expression of Melan-A in depigmented lesions of vitiligo patients. Methods: A descriptive study aimed to describe the expression of Melan-A in the depigmented skin of vitiligo patients at the Dermatovenerology Outpatient Clinic Cosmetic Division of Academic General Hospital Dr. Soetomo Surabaya. Eleven study subjects were selected through a sequence of selection. Results: Melan-A expression in the depigmented skin of vitiligo patients was lower than the average. This result was found in 6 (54.55%) out of 11 patients. Conclusion: Melan-A expressions on depigmented skins of vitiligo patients are generally below the average value; therefore, adequate intervention is needed to increase the Melan-A expression.

Item Type: Article
Uncontrolled Keywords: Vitiligo, Melan-A/MART-1
Subjects: R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Kulit dan Kelamin (Spesialis)
Creators:
CreatorsNIM
Tjokorde Istri Nindya Vaniary, -UNSPECIFIED
M. Yulianto ListiawanNIDN8806800016
Dwi Murtiastutik, -NIDN8860010016
Depositing User: arys fk
Date Deposited: 17 Jan 2023 13:45
Last Modified: 17 Jan 2023 13:45
URI: http://repository.unair.ac.id/id/eprint/119598
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