Adinda Juwita Syakila Elizafanti, - and Maria Inge Lusida, - and Muhammad Miftahussurur, - and Alpha Fardah Athiyah, - (2022) Human Norovirus Molecular Analysis and Development of Norovirus Vaccine. Indonesian Journal of Tropical and Infectious Disease, 10 (1). pp. 8-17. ISSN 2356-0991

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Abstract

The most common organism of acute viral gastroenteritis is norovirus, which accounts for roughly 20% of all occurrences of acute gastroenteritis globally. The virus kills over 200,000 children each year and is the leading cause of childhood diarrhea in the rotavirus-vaccinated population. This study aims to review available studies regarding the information on the genogroup norovirus in humans, development of norovirus vaccines, and effectiveness of norovirus vaccines. A systematic review using Science Direct, PubMed, and Scopus databases to identify eligible case studies. The search was conducted in September-October 2021. The quality of the included literature used checklists from the Critical Appraisal Skills Program (CASP). All of the six selected studies with populations given RT-PCR intervention showed positive for norovirus infection. The most predominant genogroups in humans are GI and GII. As for the research results of the two selected studies on norovirus vaccine, namely the human phase 2 trial containing two Virus-Like Particles (VLP) genotypes, one study showed efficacy at 18-49 one study at ≥ 60 years of age. This study analysis uses Takeda bivalent vaccine. The vaccine includes norovirus antigens of the GI and GII genogroups, intending to expand its protective immune potential. GI, GII, and GIV genogroups are prevalent in humans. VLP that contains GI.I and consensus GII.4c have been created as the NoV vaccine, providing signifi cant efficacy. Very likely because they contain GI dan GII antigens, which are the genogroups that infect humans the most. Patients given a placebo developed acute gastroenteritis due to norovirus GII.2, indicating a genotype cross-reactivity.

Item Type:	Article
Uncontrolled Keywords:	Norovirus, Genogroups, Vaccine, Human, Systematic
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Divisions:	01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:	Creators NIM Adinda Juwita Syakila Elizafanti, - UNSPECIFIED Maria Inge Lusida, - NIDN0017095807 Muhammad Miftahussurur, - NIDN0029097909 Alpha Fardah Athiyah, - NIDN0023087301
Depositing User:	arys fk
Date Deposited:	23 Jan 2023 15:52
Last Modified:	23 Jan 2023 15:52
URI:	http://repository.unair.ac.id/id/eprint/119643
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