Paulus Sugianto, - and Widiana Ferriastuti, - and Kiking Ritarwan, - and Dwi Putri Rahayu Tampubolon, - (2022) Medicinal Plants - A Promising Breakthrough in the Management of Alzheimer's Disease Progression Compared to NSAID: A Systematic Review. Bali Medical Journal, 11 (3). pp. 1982-1986. ISSN 2089-1180

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Abstract

Treatment of Alzheimer's Disease is currently limited only to slowing the progression of the symptoms, not curing the disease. Current FDA-approved therapies such as Donepezil, Tacrine, Galantamine, Rivastigmine, and Memantine have quite disturbing side effects, as well as the mechanism of action of these drugs, which is dominated by working as AChE inhibitors. On the other hand, the hypothesis for Alzheimer's causes is varied. Another study also states that Non-Steroid Anti-Inflammatory Drugs (NSAIDs) can be given to people with Alzheimer's. However, the reports were conflicting as one study stated that NSAIDs can help reduce the risk of Alzheimer's; on the contrary, other studies have argued that giving NSAIDs to people with Alzheimer's is not necessary. Despite administering Alzheimer's drugs and NSAIDs, which have adverse side effects on long-term use and high doses, the administration of traditional medicines and medicinal plants can be a good solution due to lower side effects than common drugs, less risk, easy access and affordable. These medicinal plants have several mechanisms to counter the hypothesis that causes Alzheimer's disease.

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