Muhammad Hasan Al Banna, - and Paulus Sugianto, - and Maftuchah Rochmanti, - (2023) Study of The Use of Antibiotics in Meningoencephalitis Patients at Dr. Soetomo Hospital in 2019—2020. International Journal of Research Publications, 116 (1). pp. 26-31. ISSN 2708-3578

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Abstract

Background: Encephalitic meningitis became the 17th ranked disease in Indonesia in 2007, with a mortality proportion of 0.8%. Every patient with suspected encephalitic meningitis needs to be given antibiotics as empiric therapy while waiting for the results of the culture from the lumbar puncture. In fact, the administration of these antibiotics cannot be separated from the risk of resistance, so monitoring and evaluation is needed in administering antibiotics to patients to prevent resistance. This study aims to determine patient profiles, patterns, and appropriateness of antibiotic use in meningitis and/or encephalitis patients at RSUD DR. SOETOMO in 2019— 2020. This is a retrospective observational descriptive study with a total of 82 medical records in patients diagnosed with meningitis and/or encephalitis who were given antibiotics as empiric therapy at RSUD DR. SOETOMO in 2019— 2020. The age of the patients from the 82 data obtained varies quite a bit, but the final elderly aged 56-65 years had the highest number, namely 16 of 82 patients (20%). Then, the sex of the most patients was found in male sex with a total of 49 of 82 with a ratio of men and women was 3:2. Most of the patients final conditions were found in the final condition of death with a total of 42 of 82 patients (51%). All of the antibiotics used were Ceftriaxone by injection route in 12-hour intervals. The most frequently used dose was 2 grams (89%), and the most frequently used duration was 7 days (21%). The results of the Gyssen method analysis showed that there were 78 (95%) I category, 1 (1%) IIIa, and 3 (4%) IIIb. DDD per 100 days of hospitalization in this study was 66.2 DDD/100 days of hospitalization. The majority of meningitis and/or encephalitis patients had a final elderly age of 56-65 years, were male, and died in the final condition. Empiric antibiotics were used entirely with Ceftriaxone intravenously at 12 hourly intervals. Most of the antibiotics are given within 7 days and the dose is 2 grams. The results of the analysis found that 95% of the use of antibiotics was already appropriate.

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