Sindy Cornelia Nelwan, - and Udijanto Tedjosasongko, - and Satiti Kuntari, - and Haryono Utomo, - and Tania Saskianti, - and Mega Moeharyono Puteri, - and Devi Dharmawan, - and Yufita Fitriani, - and Pradita Agung Kurnia, - and Amalia Ramadhani Mufida, - and Nadhia Zahria Fajrin, - (2021) The Effect of Uv-B Exposure and Vitamin K2 on the Bone Formation in Covid-19 Pandemic Era. Journal of International Dental and Medical Research, 14 (3). pp. 1008-1013. ISSN 1309-100X

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Abstract

Vitamin D deficiency is malnutrition that occurs in developed and developing countries, which worsened by Covid-19 pandemic. Covid-19 pandemic forces all activities doing from home (e.g., study and work from home). Reduced activity outside the home causes less UV-B exposure that beneficial for vitamin D synthesis endogen (>80%). The role of UV-B lamp considered more effective than the sun exposure with unstable intensity. The use of a UV-B lamp is one of new alternative to overcome vitamin D deficiency. Except the UV-B, the vitamin D3 and K2 are also effective in activating vitamin D. It claimed that combination of vitamin D3 and K2 is more effective in activating active vitamin D than single dose of the vitamin itself thus enhancing bone formation markers within the serum. In vivo experimental study conducted in 96 rattus novergicus. The total sample was 96, consisting of 48 BALP serum level groups and 48 OCN serum level groups. The sample divided into six groups, consisting of one control group and five experimental groups (UV-B, Vitamin D3, and K2). A significant difference was found. ANOVA and paired t-test used to compare the results of each group. An increase was found in all BALP and OCN serum level groups, compared to the control group. A significant difference was found in all BALP and OCN serum level groups (P <0.005). Combination of 290-315 nm of UV-B, vitamin D3, and K2 supplements improve bone formation marker production in the serum (BALP and OCN)

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