Fitriah (2010) Polimorfisme Gen Plamodium Falciparum DHFR dan DHPS pada Ibu Hamil Yang Menderita Malaria Falciparum di Kabupaten Banjar,Provinsi Kalimantan Selatan. Thesis thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Pregnant women are highly vulnerable to malaria infection in malaria endemic areas, particularly infected with P. falciparum that can cause premature, low birth weight (LBW), severe anemia in pregnant women, and death, Sulfadoxine¬pyrimetharnine (SP) for Intermittent Preventive Treatment for pregnant (IPTp) is used for malaria control in pregnancy by World Health Organization's recommendation that has already been implemented in Africa, The P. falciparum resistance to SP has occurred in several malarial endemic areas, and the mutation gene of PfDHFR and PfDHPS is associated with parasite resistance to SP treatment. Mutation gene of PfDHFR and PfDHPS in pregnant women infected with P. falciparum has not yet been examined in Indonesia, The cross-sectional study was conducted, and 127 pregnant women were recruited randomly from 2008 to April 2010 at two subdistricts, Sungai Pinang and Peramasan, in Banjar district, South Kalimantan Province. Mutation gene of PfDHPS and PfDHFR analyzed by nested PCR-RFLP method resulted six of seven samples of pregnant women infected with P. falciparum have triple mutations consisting of double PfDHFR (N 108 and 151) and single- mutation gene PfDHPS (0437). One sample had quadruple mutations consisting of double PfDHFR (S108N and NMI) and double PIDIIPS (G437 and E540). These results suggested that P. falciparum resistance to SP may occur at Sungai Pinang and Peramasan subdistricts, Thus, these study results could be used as a recommendation for malaria control policy in pregnant women at malaria endemic areas in Indonesia, particularly the implementation of IPTp in Banjar District, South Kalimantan Province
| Item Type: | Thesis (Thesis) | |||||||||
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| Additional Information: | KKA KK TKD 06/11 Fit p | |||||||||
| Uncontrolled Keywords: | P. falciparum, Pregnant women, gen PIDHFR, gen PfDHPS | |||||||||
| Subjects: | R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics > RG500-991 Obstetrics > RG551-591 Pregnancy | |||||||||
| Divisions: | 01. Fakultas Kedokteran > Magister Ilmu Kedokteran Dasar | |||||||||
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| Depositing User: | Sulistiorini | |||||||||
| Date Deposited: | 16 Mar 2023 07:59 | |||||||||
| Last Modified: | 16 Mar 2023 07:59 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/120613 | |||||||||
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