Dina Priliasanti S, - (2010) Curcumin Menurunkan Ekspresi Nuclear Factor-Xb Plasenta Dan Kadar Malondealdehid Serum Pada Mus Muscuius Model Preeklampsia. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Objective: Curcumin, derived jrom the plant Curcuma that is a commonlv used not only as spice but also as medicinal plants. C'urcumin has heen shown to exhibit antioxidant, anti-inflamatory, and anti-platelet. These effects are mediated through the regulation of variotcs transcription factors, inflamatory cytokines, protein kinase. and other enzimes. Thus, has a potential against oxidative stress-related and inflamatory illness, Preeclampsia. This study compare NF-KB expression and malonedialdehide assesment (as a marker of oxidative stress gradation) between preeldamptic mice model treated with two different dose curcumin and control. Method: Experimental study, randomized controlled double blind controlled trial. Three mice groups, preeklamptic induced by injection of anti-Qa2 antihody. One group treated with 100 mg/kgBW of curcumin, other group with 240 mg/kgBW of curcumin, and one control group (aquades as plasebo). Those treatment given daily until 14 days. The mice were sacrificed, placentas ►1,c3re taken for NF-KB expression assesment with immunohistochemistry staining method, the serums were taken for malonedialdehide assesment. Result: There are sigrnficant differences in NF-KB assesment between group treated with 100 mg/kgBW of curcumin and control (1,5111±0,2922), group treated with 240 mg/kgBW of curcumin and control (1,0000 0,2922). But there is no significant dijjerence between group treated by 100 mg/kgBW of curcumin and group treated by 240 mg/kgBW of curcumin (-0,5111±0,2922). There are significant differences in malonedialdehide amount between group treated with 100 mg/kgBW of curcumin and control (mean difference 2,7320+0,3042), group treated with 240 mg/kgBW of curcumin and control (mean difirence 3,5334±0,2612), between group treated with 100 mg/kgBW of curcumin and group treated with 240 mg/kgBW of curcumin (mean difference 0,8014+0,1624). Conclusion: Curcumin decrease NF-KB expression and malonedialdehide amount in preeklamptic mice model. The decreasing is dose dependent. At dose 240 mg/kgBW. curcumin might have pro-oxidant effect that cause decreasing of curcumin antioxidant activity.

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