Endang Sriwahyuni, - (1999) Pengaruh Alkil Benzen Sulfonat Dalam Deterjen Terhadap Respons Imun Mukosa Usus Mencit Mus Musculus Balb/C Paradigma Patobiologis Yang Berkonsep Pada Stress Cell. Disertasi thesis, Universitas Airlangga.

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Abstract

In developed countries, the use of ABS as material source to produce detergent has been prohibited due to its toxicity effect, which is hazardous for human beings health. In Indonesia ABS is still used by most detergent industries as material source to produce detergent due to its lower cost and easy availability. Such industries and household still use rivers to dispose their detergent waste, which make those rivers exposed to ABS. At the same time, in Indonesia, rivers are still used as the largest source for water supply. Until now, ABS cannot be eradicated from water supply processed from ABS- exposed rivers. Up to this time, the effects of ABS exposure to gut mucous have not been disclosed. This study was intended to disclose such problem using experimental animals, which were exposed to ABS & LAS solution. Because ABS is a genotoxic substance, this substance can act as cell stressor. If the cell is included in immunocompetence cell, stress may also occur in the immune system. Therefore, the author used pathobiological paradigm based on stress cell concept. Immune system variables used in this study were T CD4 + lymphocyte, T CDs + lymphocyte, SP IgA, SP IgM, SP IgG, NK. and M0. Animals used in this study were thirty male mice, aged 45-60 days, which were divided into three groups. The first group was given 0.1 cc solution with 6.25 mg ABS per day, the second group was given 0.1 cc solution with 6.25 mg LAS per day, and the last one was given 0.1 with aqua per day, each for 7 days respectively. Significant difference was evidence for the mucosal response immune between ABS exposed group and LAS exposed group on mucosal inductive area

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