Achmad Ilham Rizwani, Achmad and Arifa Mustika, Arifa and Lindawati Alimsardjono, Lindawati and Tri Hartini Yuliawati, Tri and Priyo Budi Purwono, Priyo Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 10 (1). pp. 5-10. ISSN p(1907-3623) e(2684-9453)

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Abstract

Introduction: Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistance. Mangosteen (Garcinia maangostana) peel had a therapeutic potency for Shigella dysenteriae infection due to its antibacterial and anti-inflammatory activity. Methods: The research was experimental, 30 mice were used which was divided into 5 groups. The mice were infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) peel were given for each group for 5 days, which then the mice’s colon were collected and made into histology specimen and its mucosal destruction was observed in three fields of view in each specimen, 1 – 4 score was given according to its mucosal destruction. Kruskal-Wallis test was used to analyze the data and then Mann Whitney test also used for further analysis. Results: There was colon mucosal improvement observed when mangosteen (Garcinia mangostana) peel extract was given, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) peel extract already given a positive effect on mice’s mucosal colon histology appearance, no difference observed between the 3 doses given. Conclusion: Mangosteen (Garcinia mangostana) peel extract gave appearance improvement to the colon mucosal wall of mice with Shigella dysenteriae infection at the dose of100 mg/Kg body mass

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