Nove Hidajati, - (2001) Sifat Antioksidan Bawang Putih (Allium Sativurn) Yang Berperan Sebagai Hepatoprotektor Pada Tikus Putih (Rattus Norvegicus Galur Sprague Dawley) Yang Diinduksi Dengan Cci4. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study was aimed to identify the role of garlic as antioxidant and hepatoprotector on CCI4-induced rat. Experimental laboratory method was used in this study. Three different treatments (garlic extract of 2.5 g/kg bw, 5 g/kg bw, and 10 glkg bw) were given everyday for 8 days. Two control, negative and positive, were used for comparison. MDA (malondialdehyde) examination was performed using TBA (thiobarbituric acid) test, serum GPT (glutamate pyruvate transaminase ) , and histopathological examination. Results showed that garlic administration of 10 g/kg bw could prevent the increase of MDA concentration, the occurrence of centrilobular necrosis, and the increase of GPT concentration. It indicated that garlic dose of 10 g/kg bw had antioxidant and hepatoprotective activity on CCI4-induced rat.

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