Eko Prihiyantoro (2000) Perkembangan Embrio Mencit (Mus Musculus) Preimplantasi Setelah Induksi Ovulasi dengan Klomifen Sitrat pada Induknya: Penelitian Eksperimental Laboratoris. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The objective of this study is to investigate the effect of clomiphene citrate on ovulation, fertilization and embryonic development in mice The ovulation process was detected indirectly by counting the number of corpus luteum, fertilization was detected by• the number of embryo and embryonic development was detected by the percentage of blastocyst formation. The design of the study is true experimental using 3x3x5 factorial includes dose factor (3), mating times (3) and replications (3). The dose factor consist of 0 μg/g, body weight.; :2.5 μg/g body weight; 5,0 μg/g body weight The mating time consist of after once injection;. after twice injection; a day after twice injection. On the 3rd day of gestation, mice were sacrificed by cervical dislocation, then ovary and uterus were collected. Corpus luteum was counted by dissecting microscope and the embryos were collected by flushing uterus. Embryos were obtained and counted then development stages of embryo were observed. From this study it may be concluded that clomiphene citrate increased ovulation rate and fertilization rate but decreased embryos quality.

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