WIDYA PRATIWI, ,- and Lucia Tri Suwanti, ,- and Woro Hastuti Satyantini, ,- (2016) PERENDAMAN EKSTRAK Spirulina plantesis TERHADAP Ig-M, JARINGAN LIMPA DAN DIFERENSIAL LEUKOSIT IKAN MAS SETELAH DIINFEKSI Aeromonas hydrophila. Jurnal Biosains Pascasarjana, 18 (3). ISSN 1412-1433

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Abstract

Disease of Motile Aeromonad Septicemia (MAS) is a bacterial disease that often attacks the carp (Cyprinus carpio) and the type of tropical freshwater fish other.The appearance of bacterial disease because of infection Aeromonas hydrophila and known as a red spot disease. Diseases caused by A. hydrophila, making blooding on part of body such as skin, stomach and the base of the fin, which disease can caused death in farmed fish. One of the efforts to prevent the spread of diseases caused by bacteria so giving natural ingredients that can modulate the immune system. Immunomodulator is a compound that can modulate (weaken or strengthen) the immune response. One result of the sea that can be used a medicine and has many benefits is Spirulina platensis. Spirulina platensis has phenolic and flavonoid compound. Compounds of flavones and phenol groups have been shown to increase the immune response. The research was conducted in Mei 2016 and was completed in July 2016 which was done in the Faculty of Fisheries and Marine Airlangga University Surabaya. This study aimed to analyze the effect of extracts of Spirulina platensis on levels of Ig-M, histopathology of spleen and differential leukocyte value in carp after infected A. hydrophila. Giving extraction of S. platensis made by deeping. Deeping of extracts S. platensis made after A. hydrophila infected in Carp. Deeping done 2x, the second day and the seventh day after infection with A. hydrophila. Dose deeping consist are 0 ppm (control), a dose of 50 ppm, 100 ppm and 200 ppm. Deeping time performed for 30 minutes. The results was showed immersion S.platensis extract dose of 200 ppm on day 7 that make increase of Ig-M, differential leukocyte and make low damage of structure spleen tissue carp caused attack from A. hydrophila.

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