Michael J. Kridanto Kamadjaja, - and Sherman Salim, - and Gigih Gemiudeas, - (2022) The Effect Of Scaffold Hydroxyapatite Derived From Portunus Pelagicus Shell On The Expression Of Fibroblast Growth Factor-2 (Fgf-2) And Bone Morphogenetic Proteins-2 (Bmp -2) In The Extraction Sockets Of Cavia Cobaya. Journal of Oral Research, 11 (5). pp. 1-10. ISSN 0719-2479

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Abstract

Objetive: To determine the expression of Fibroblast Growth Factor (FGF)-2 and Bone Morphogenetic Protein (BMP)-2 after application of scaffold hydroxyapatite from Rajungan crab shell (Portunus pelagicus) in the toothextraction socket of Cavia cobaya. Material and Methods: This study used a post-test only control group design with 28 Cavia cobaya separated into two groups, control and treatment group. The left mandibular incisor was extracted and socket preservation was conducted. A hydroxyapatite graft derived from crab shells was mixed with gelatin and eventually turned into a scaffold, which was afterwards put into the extraction socket. After 7 days and 14 days, each group was terminated and examined using immunohistochemical staining to observe the expression of FGF-2 and BMP-2. One-Way Anova and Tukey HSD were used to examine the research data. Results: FGF-2 and BMP-2 expressions were observed higher in the group that received hydroxyapatite scaffold at the post-extraction socket than those in the group that did not receive hydroxyapatite scaffold. Conclusion: The application of a hydroxyapatite scaffold from Rajungan crab shell (Portunus pelagicus) to the tooth extraction socket can increase FGF-2 and BMP-2 expression.

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