Gwenny Ichsan Prabowo and Margarita Maria Maramis and Erikavitri Yulianti and Afrina Zulaikah and Zain Budi Syulthoni and Hendy Muagiri Margono and Retno Handajani (2018) The frequency of DISC1 Leu607Phe gene polymorphism in schizophrenia patients at Dr. Soetomo General Hospital Surabaya. Berkala Ilmu Kedokteran (Journal of the Medical Sciences) J Med Sci, 50 (01). pp. 15-23. ISSN 356‐3931

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Abstract

Schizophrenia is a common health problem in the world, including in Indonesia. Polymorphism of gene disrupted in schizophrenia 1 (DISC1) Leu607Phe is allegedly related to the predisposition to schizophrenia. However, studies on the relationship between polymorphism of DISC1 Leu607Phe and schizophrenia in various ethnics provided different results.The purpose of this study was to determine the frequency of DISC1 Leu607Phegene polymorphism and its association with treatment response in patients with schizophrenia at Department of Psychiatry, Dr. Soetomo General Hospital Surabaya.In this study, the number of male patients with schizophrenia was more than that of the female patients. The mean age of male patients with schizophenia was lower than that of the female patients. Schizophrenia patients were primarily came from Javanese ethnic with positive and negative symptom score (PANSS) lower in male patients than that in the female patients. In conclusion, no DISC1 gene polymorphism at codon 607 is observed in schizophrenia patients at Dr. Soetomo General Hospital Surabaya, but the G nucleotide variation at the number 196.339 in intron regions is found instead.

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