Ari Alauddin Mawdudi, Ari and Furqan Hidayatullah, Furqan and Indra Bachtiar, Indra and Arif Rachman, Arif and Indri Lakhsmi Putri, Indri and Fabio Castiglione, Fabio and Wahjoe Djatisoesanto, Wahjoe and Lukman Hakim, Lukman The Effect of conditioned-Medium Human Adipose-Derived Mesenchymal Stem Cell In Apoptosis Of Bladder Cancer Cells. Indonesian Journal of Urology, 28 (1). ISSN p(0853-442X) e(2355-1402)

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Abstract

Abstract Objective: To determine the effect of conditioned medium human Adipose-Derived Mesenchymal Stem Cells (CM-hADMSC) on apoptosis of urothelial bladder cancer cells. Material & Methods: Bladder (5637) cancer cell lines cultured in conditioned media harvested from human adipose-derived mesenchymal stem cells (hADMSC). Flow cytometry tests were carried out using the Flowcytometry Acquisition cell sorting (FACS) Calibur to measure apoptosis. Results: There was a significant difference in the percentage of late apoptosis in the group receiving culture medium treatment: CM-hADMSC 1: 1 to the entire study group. Further analysis revealed no difference in the average percentage of late apoptosis in groups exposed to culture medium: CM-hADMSC 1: 2 and culture medium: CM-hADMSC 1: 4 (p> 0.05). Conclusion: CM-hADMSC at a 1: 1 dose concentration to culture medium obtain a significant increase of apoptosis in bladder cancer cells.

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