Hayati, - and Jusak Nugraha, - and Bambang Purwanto, - and Hari Basuki Notobroto, - and Yoes Prijatna Dachlan, - and Hari Setiono, - and Idha Kusumawati, - (2022) Qualitative Analysis of Cinnamomum burmannii Content using GCMS (Gas Chromatography Mass Spectometry) Method. Indian Journal of Forensic Medicine & Toxicology, 16 (1).

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Abstract

To identify the bioactive compounds in Cinnamomum burmannii and their biological activity. Cinnamon bark originating from Batu Malang, East Java, which was located 700-1300 meters above sea level, was processed into dry extract by maceration method with 96% ethanol solvent. Furthermore, cinnamon ethanol extract was analyzed using the GCMS method to look at the content of the bioactive component for further testing biological activity with the server Way2Drug PASS. GCMS results showed 40 active compounds such as trans-cinnamaldehyde, trans-anethole, cinnamyl acetate, calacorene, cadina-1, 4-diene, delta-cadinene. Furthermore, of the 40 compounds, the biological activity potential was tested for 29 bioactive compounds based on PA (probable to be active) values predicted by the Way2Drug PASS server. Cinnamomum was tested against the potential as anti-fungi, anti-bacterial, anti-oxidant, anti-inflammatory, anti-diabetic, anti-neoplastic. Trans-cinnamaldehyde showed PA 0,583 as anti inflammatory, L-limonene PA0,818 as anti neoplastic, Tans-anethole PA 0,614 as anti neoplastic, Cinnamyl acetate PA 0,669 as anti inflammatory, calacorene PA 0,698 as anti inflammatory, Delta cadinene PA 0,651 as anti neoplastic, , Cathechin PA 0,828 as anti oxidant, alpha.-Cubebene PA 0,888 as anti inflammatory and PA 0,837 as anti neoplastic, melilotin PA 0,929 as anti neoplastic, Caryophyllene PA0,915 as anti neoplastic. Cinnamomum burmannii had biological potency based on potential activity (PA) 0,432 (+0,117) as antifungi, PA 0,335 (+0,090) as antibacterial, PA 0,304 (+0,199) as antioxidan, PA 0,561 (+0,190) as anti inflammatory, PA 0,373 (+0,170) as antidiabetic, PA 0,584 (+0,234) as antineoplastic.

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