Prastiya Indra Gunawan, Prastiya (2023) Neuropsychiatric Disease and Treatment. Dove Medical Press invites.
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Abstract
Abstract: Purpose: Neuron specific enolase (NSE) is considered as a biomarker for the severity of nervous system diseases. We sought to explore whether serum NSE concentration in ischemic stroke patients undergoing mechanical thrombectomy (MT) is related to 3-month functional outcome and symptomatic intracranial hemorrhage (sICH). Patients and Methods: We retrospectively collected the data of acute ischemic stroke patients with anterior circulation infarction receiving MT within 6 h in our stroke center. Favorable outcome and poor outcome at 3 months were defined as modified Rankin Scale (mRS) score 0-2 and 3-6, respectively. sICH was defined according to the Heidelberg bleeding classification. We used multivariate logistic regression model and receiver operating characteristic curves to investigate the correlation between NSE and the clinical outcomes. Results: Among the 426 patients enrolled, 40 (9.4%) patients developed sICH. 3-month favorable outcome in 160 (37.6%) and poor outcome in 266 (62.4%) patients were observed. Serum NSE levels was significantly correlated with 3-month mRS score (R = 0.473, P < 0.001). A cutoff value of 15.29 ng/mL and 23.12 ng/mL for serum NSE was detected in discriminating 3-month poor outcome (area under the curve, 0.724) and sICH (area under the curve, 0.716), respectively. Multivariate analysis showed that high serum NSE levels were independently associated with 3- month poor outcome (odds ratio [OR] 5.049, 95% confidence interval [CI] 2.933-8.689, P＜0.001) and sICH (OR 5.111, 95% CI 2.210-11.820, P < 0.001). Conclusions: Our study demonstrated that high serum NSE levels after receiving MT were independently associated with 3-month poor outcome as well as sICH in acute ischemic stroke patients. Serum NSE levels could be a good predictor of prognosis for patients receiving MT.
| Item Type: | Other | ||||
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| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) | ||||
| Divisions: | 01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis) | ||||
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| Depositing User: | arys fk | ||||
| Date Deposited: | 30 Apr 2023 12:54 | ||||
| Last Modified: | 30 Apr 2023 12:54 | ||||
| URI: | http://repository.unair.ac.id/id/eprint/125791 | ||||
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