Junairiah*, .- and Ni’matuzahroh and Nabilah Istighfari Zuraidassanaaz, .- and lilis Sulistyorini, .- (2017) Antifungal and antibacterial activity of black betel (Piper betle L. var Nigra) extract. Bioscience Research, 14 (4). pp. 2797-2802. ISSN Print ISSN: 1811-9506 Online ISSN : 2218-3937

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Abstract

Black betel (Piper betle L. var Nigra) belong to Piperaceae family and one of endemic species of Indonesia. This study was aimed to determine antifungal and antibacterial activity of n-hexane, ethyl acetate, and methanol extracts of Piper betle L. var Nigra toward pathogenic microbes Candida albicans ATCC 10231, Staphylococcus aureus ATCC 25923, and Escherichia coli ATCC 25922. Leaf powder of black betel was macerated using n-hexane, ethyl acetate, and methanol solvents. Antifungal and antibacterial activity was determined using diffusion and dilution tests. Data collected from both tests including diameter of inhibition zone (mm) and Minimal Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), Minimal Fungicidal Concentration. Data was then analyzed statistically. Result showed that methanol extract of black betel had the highest inhibition activity compared to n-hexane and ethyl acetate extract.

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