Siti Febtria Asrini Sugito, .- and Fakhri Firdaus, .- and Yu Aung, .- and Satya Candra Wibawa Sakti, .- and Hsien-Tai Chiu, .- and Mochamad Zakki Fahmi*, .- (2022) In situ tailoring of carbon dots-metal ferrite nanohybrid as multipurpose marker agent of HeLa cancer cells. Journal of Materials Research, 37 (2022). pp. 1941-1951. ISSN 0884-2914, 2044-5326

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Abstract

The development of multifunction material was considered to attain effectiveness on cancer treatment. The present study pursues the potential application of metal ferrite nanoparticles covered with CDs to get dual-active nanomaterial on fluorescent and magnetic responses that were prepared on a one-pot solvothermal method. Some analyses indicated the nanohybrids consisted of amorphous structure. Besides, the optical analysis performed optimum emission with QY percentage up to 0.9 and 0.6, respectively. Magnetic response assessment confirmed CDs@MnFe2O4-15 has good superparamagnetic properties with saturation magnetization value of 38.485 emu/g, while CDs@CuFe2O4-15 at 9.5245 emu/g. The DLS measurement showed an average size of CDs@MnFe2O4-45 at 63.98 nm, while CDs@CuFe2O4-45 at 55.46 nm. Then, this nanosized drive to perform good photoluminescent properties and good cytotoxicity due to the nanohybrids of CDs@MFe2O4-45 can easily enter the HeLa cells without harming its original structure. The above finding has well-proven good clinical potency of the nanohybrid as simultaneous fluorescent and magnetic-based detection.

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