Hendy Stio Iwantono, - and Etty Hary Kusumastuti, Etty and Alphania Rahniayu, Alphania Correlation Between PDL-1 and P16 Expression In Cervical Squamous Cell Carcinogenesis. Biochemical and Cellular Archives, 21 (1). ISSN 2632-9433

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Abstract

ABSTRACT : Human papillomavirus (HPV) infection caused a morphological change known as Low-grade squamous intraepithelial lesion (LSIL). Certain type of HPV infection could become persistent and progress to High-grade squamous intraepithelial lesion (HSIL), which are high risk of becoming invasive cancer, Squamous cell carcinoma (SCC). Immunohistochemical staining with p16 known as the marker on cervical lesion caused by HPV infection, p16 strongly expressed on HSIL and SCC, but very weak to none on LSIL or HPV negative. Programmed Death Ligand 1 (PDL-1) pathway has an important role in decreasing T cell response and promoting T cell tolerance on chronic viral infection.Analyzing correlation between PDL-1 and p16 expressions with LSIL, HSIL and SCC of the cervix. Analytical observational conducted on paraffin block samples of the LSIL, HSIL and SCC of the cervix, at the Anatomical Pathology laboratory, Dr. Soetomo Academic General Hospital, Surabaya. Immunohistochemical staining is performed to detect expression of PDL-1 and p16. The result was statistically analyzed using Chi-Square correlation test. There are marked positive correlation between P16 and PDL-1 with LSIL, HSIL, SCC (p<0.05) with positive correlative coefficient of 0.647. There is a marked positive correlation between P16 and PDL-1 with LSIL, HSIL, SCC.

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