Selamat, - and Aditiawarman, - (2012) Clinical and laboratory profiles relationships of preeclampsia-eclampsia patients with maternal mortality in dr. soetomo hospital, surabaya. Majalah Obstetri & Ginekologi, 20 (1). pp. 35-39. ISSN 0854-0381

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Abstract

Preeclampsia-eclampsia is one of the most common complications of pregnancy and one of the highest causes of maternal mortality in developing countries. It becomes a major cause of maternal deaths that are difficult to prevent, unless the clinical condition of the mother with laboratory profiles can be identified quickly and well understood. The objective of this research was to study the relationship between clinical and laboratory profiles of preeclampsia – eclampsia patients with incidence of maternal mortality. This study was a retrospective observational analytic studies in patients with preeclampsia-eclampsia were treated in Dr. Soetomo hospital between January 2009 and December 2011. Data were retrieved from Dr. Soetomo Hospital Surabaya medical records. The assessed variables were clinical conditions (pulmonary edema, cerebral edema, intracerebral hemorrhage, HELLP syndrome, DIC, renal failure and retinal detachment) and laboratory (hemoglobin, leukocytes, hematocrit, platelets, GDA, SGOT, SGPT, BUN, SK, Na, K, albumin, LDH) and the outcomes (alive or dead). Data were processed using SPSS software. On each of the variables logistic regression test was performed. It was faund that during the 3-year period there were 247 cases of preeclampsia-eclampsia with maternal mortality rate 10.5%. ALT> 40 U/L (p = 0.001) and Platelets count <150.000 /µL (p = 0.0001) had a significant relationship with the incidence of maternal mortality in HELLP syndrome. Creatinine serum > 1.2 mg/dL (p = 0.0001) had a significant relationship with the incidence of maternal mortality in ARF. Pulmonary edema had a significant relationship with the incidence of maternal mortality (p = 0.0001). Platelets count <150000 /µL had a significant relationship with the incidence of maternal death in cerebral edema (p = 0.0001). In conclusion, clinical profiles in preeclampsia-eclampsia patients who died in Dr. Soetomo Hospital, Surabaya, has correlation with their laboratory profiles.

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