The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus

Ike Wahyu Triastuti, - and Roedi Irawan, - and Anang Endaryanto, - and Nur Rochmah, - and Muhammad Faizi, - (2022) The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus. International Journal of Scientific Advances, 3 (2). pp. 280-283. ISSN 2708-7972

WarningThere is a more recent version of this item available.
[img] Text (Artikel)
30 - Artikel.pdf

Download (6MB)
[img] Text (Kualitas Karil)
30 - Kualitas Karil.pdf

Download (258kB)
[img] Text (Turnitin)
30 - Turnitin.pdf

Download (1MB)
Official URL: https://www.ijscia.com/?p=9572

Abstract

Type 1 diabetes mellitus (T1DM) is a disease caused by dysregulation of the immune system with pancreatic cells as the targeted organ. The incidence of T1DM is increasing every year, with peak incidence at the age of 10-14 years. Genetic susceptibility and environmental exposure play important roles in immune system disorders. The failure of the tolerogenic process is one of the foremost processes causing pancreatic damage through the molecular mimicry process due to repeated infections both prenatally and postnatally. An increase in the expression of MHC class II and co-stimulator will trigger a shift in the balance of the shape of T cells, namely an increase in Th1 and Th7 cell differentiation, but a decrease in the number and function of Treg cells. TGF-β is a cytokine produced by Treg cells that functions to maintain tolerance in the human body. A decrease in TGF-β levels usually appears in the pre-diabetes stage. This review aims to elucidate the role of TGF- in the course of T1DM.

Item Type: Article
Uncontrolled Keywords: T1DM; molecular mimicry; Treg; TGF-β
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:
CreatorsNIM
Ike Wahyu Triastuti, -UNSPECIFIED
Roedi Irawan, -NIDN8853800016
Anang Endaryanto, -NIDN8867700016
Nur Rochmah, -NIDN0029047909
Muhammad Faizi, -NIDN8890900016
Depositing User: Mrs Elok Dian Nuraeni
Date Deposited: 29 May 2023 23:02
Last Modified: 29 May 2023 23:02
URI: http://repository.unair.ac.id/id/eprint/126823
Sosial Share:

Available Versions of this Item

Actions (login required)

View Item View Item