Ni Made Inten Lestari, - and Evelyn Komaratih, Evelyn and Fedik A. Rantam, - and Yuyun Rindiastuti, - and Cita Rosita Sigit Prakoeswa, - Therapeutic Potential of Limbal Mesenchymal Stem Cell Secretome for Repair Ocular Surface in Experimental of Dry Eye Disease. International Journal of Research Publications (IJRP.ORG), 83 (1). ISSN 2708-3578

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Abstract

Abstract Background: The objective of this study to explain relationship limbal mesenchymal stem cell secretome (L-MSC) for repair ocular surface in experimental model of dry eye disease (DED) Methods: The research design used experimental study. Pre and post experimental study composed of topical instillation of limbal mesenchymal stem cell secretome group, balance salt solution (BSS) group, and normal control group. Result: Topical instillation of limbal mesenchymal stem secretome improved regeneration of corneal epithelial cell (p >0.05) and promoted goblet cell restoration (p = 0.016) Conclusion: In conclusion, topical instillation of limbal mesenchymal stem secretome has potential regenerist therapy to preserve ocular surface?in experimental DED model

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