Devi Rahmadhona, NIM011428156301 and Aryati, - (2019) C-Reactive Protein Levels of Sepsis Patients: A Comparison of Three Immunoassay Methods. Indonesian Journal of Clinical Pathology and Medical Laboratory, 26 (1). ISSN 2477-4685

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Abstract

C-Reactive Protein (CRP) is a marker to aid in diagnosing sepsis. Currently, there are not many studies about the comparison of CRP levels in sepsis patients with a variety of instruments and methods. This study aimed to analyze differences of CRP results using Particle Enhanced Turbidimetric Immunoassay (PETIA), Sandwich Immunodetection and Reflectometry Immunoassay, and to compare the characteristics of the instruments based on their specifications and practicality. The study used a total of 65 serum of sepsis patients who fulfilled the qSOFA criteria and were treated in the Emergency Department, Intensive Observation Room, Intensive Care Unit (ICU) and Internal Medicine Wards of the Dr. Soetomo Hospital Surabaya from May to September 2018. All samples were measured the CRP levels measured using the three methods. There were significant differences of CRP levels between the PETIA and Reflectometry immunoassay methods (p=0.003), suggesting a supportive role of both methods. There was no significant difference of CRP levels between PETIA and Sandwich Immunodetection (p=0.172) as well as Reflectometry immunoassay and Sandwich Immunodetection (p=0.251). The selection of instruments and methods for CRP examination must be adjusted to laboratory needs and facilities.

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