Agustin Iskandar, - and Aryati, - (2019) Correlation Between Lactic Acid Concentration And The Severity Of Neonatal Sepsis. Indonesian Journal of Clinical Pathology and Medical Laboratory, 26 (1). pp. 55-59. ISSN 2477-4685

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Abstract

In Indonesia, neonatal sepsis remains a major cause of high infant mortality rate and serve as one of the risk factors for early neonatal mortality. This study aimed to determine of the correlation between lactic acid level, the severity of sepsis, and the prognostic value of lactic acid as a predictor of neonatal sepsis severity. This study was an analytical observational research using cross-sectional method. The subjects were neonatal sepsis patients treated in the Perinatology Room of Saiful Anwar Hospital Malang from February to June 2015. The lactic acid concentration in the plasma was measured using an enzymatic colorimetric method. The results showed a positive and significant correlation (p=0.023; r= 0.414) between lactic acid concentration and severity of the sepsis, with lactic acid level of 0.151 mmol/L in every increase of sepsis. By using a cut-off ≥ 2.5 mmol/L, sensitivity and specificity of 66.7% and 76.2% were obtained, respectively. The Chi-Square test of lactic acid> 2 mmol/L and <2 mmol/L showed an Odd Ratio (OR) of 1.3. However, lactic acid level > 5 mmol/L and <5 mmol/L showed an OR of 4.8, suggesting that although there was no difference, the mortality outcome of neonatal sepsis was 4.8 times greater than those who survived. Thus, lactic acid levels > 5 mmol/L was able to determine the mortality outcome of neonatal sepsis. From this study, it was known that severity of neonatal sepsis was higher along with the higher level of the lactic acid. Lactic acid level > 5 mmol/L was the predictor for the determination of mortality outcome in the neonatal sepsis.

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