Budi Prasetyo, Budi and Diantri Nari Ratih, - and Yustinasari, - and Hilkatul Ilmi, - and Lidya Tumewu, - and Aty Widyawaruyanti, - Treadted Plasmodium berghei infected pregnant mice by – Andrographis paniculata tablet (AS201 – 01) decreasing the TLR -4 expression and apoptosis index of placental tissue. Journal of Applied Pharmmaccutical Science, 8. pp. 105-108. ISSN 2231- 3354

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Abstract

Abstract Objective: This study aimed to evaluate the effect of Andrographis paniculata tablet (AS201-01) in decreasing expression of Toll-Like Receptor-4 (TLR-4) and apoptosis index of placental tissue of Plasmodium berghei infected pregnant mice. Material and methods: A total of 24 pregnant mice were divided into 4 groups, G1 was uninfected pregnant mice group, G2 was untreated Plasmodium berghei infected pregnant mice, G3 was P. berghei infected pregnant mice treated with AS201-01 tablet and G4 was P. berghei infected pregnant mice treated with dihydropiperaquine-phosphate (DHP) tablets. All mice were sacrifice at day 15th of pregnancy and the placenta was collected. The TLR-4 expression and apoptosis index were evaluated using immunohistochemistry assay. Results: The TLR-4 expression and apoptosis index on G3 was lower than G2 and showed a statistically significant difference (P = 0.00). The TLR-4 expression and apoptosis index of placental tissue in P. berghei infected pregnant mice which treated with AS201-01 tablet were decreased compared to untreated group and DHP tablet treated group as well. Conclusion: AS201-01 tablet containing ethyl acetate fraction of A. paniculata could decrease TLR-4 expression and apoptosis index of placental tissue in P. berghei infected pregnant mice.

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