Amirotul Azhimah, - and Nunuk Dyah Retno Lastuti, - and Thomas Valentinus Widiyatno, - and Lucia Tri Suwanti, - and Poedji Hastutiek, - and Hani Plumeriastuti, - (2021) Respons Sitokin Interferon Gamma terhadap Derajat Infeksi Skabies pada Kelinci. Jurnal Veteriner, 22 (4). pp. 485-491. ISSN P-ISSN 1411-8327, E-ISSN 2477-5665

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Abstract

Scabies is an infectious skin disease caused by Sarcoptes scabiei. The role of IFN-γ on hypersensitivity reactions of scabies with different severity has not been widely reported. This study was aim to determine the role of cytokine IFN-γ in the inflammatory process and the degree of skin damage in relation to the severity of scabies infection in rabbits, so that we can determine the pathogenesis reaction of scabies in rabbits. A total of 24 rabbits that are naturally infested with S. scabiei used in this study. The rabbits were divided into four groups based on the size of the lesion and the thickness of the scales caused by scabies infection: Group 1: control negative, Group 2: Rabbits infected with mild scabies, Group 3: moderate scabies, and Group 4: severe scabies. An immunohistochemistry examination was performed on eachgroup using IFN-γ antibody. The result of the study showed that affected IFN-ã expression which was indicated by the different intensity of brownish color change on the skin tissue of rabbits infected with scabies with mild, moderate, and severe degree. Statistical analysis using Kruskal Wallis test showed that there was a significant difference on cytokine IFN-γ expression in mild scabies, moderate scabies, and severe scabies (P< 0.05). The conclusion is, in more severe scabies infection, the expression of IFN-γ to increase

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