Hartono Kahar (2022) Cut-Off Value of Procalcitonin in Sepsis and Septic Shock patients at Dr. Soetomo Hospital. Indonesian Journal of Clinical Pathology and Medical Laboratory, 28 (2). pp. 179-184. ISSN 2477-4685

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Abstract

Sepsis is a state of life-threatening organ dysfunction caused by dysregulation of the body's response to infection, and it is marked by an increase in SOFA score ≥ 2 or qSOFA score ≥ 2. Septic shock is a subset of sepsis accompanied by severe circulatory disorders that can greatly increase mortality. Although the current gold standard diagnosis method for sepsis is bacterial culture, Procalcitonin (PCT) level can help identify sepsis severity because bacterial culture requires a relatively long time. This study aims to determine the cut-off point of PCT to detect severity in patients with sepsis and septic shock. The data taken were secondary data from the medical records of sepsis and septic shock patients in Dr. Soetomo General Hospital from 2017 to 2019. The cut-off value of PCT for sepsis and septic shock was determined using Receiver Operating Characteristic (ROC) analysis curve. Most sepsis patients were young (18-65 years) (69%) (p=0.331) and male (60%) (p=0.156). There was a significant difference in PCT levels between the septic and non-septic group (p=0.000), and there was a positive correlation between PCT and sepsis. The cut-off of procalcitonin in sepsis was 0.6 ng/mL, and the cut-off of PCT in septic shock was 10 ng/mL.

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