Nur Rochmah, - and Muhammad Faizi, - and Yudhi Kurniawan, dr., - and Latifatu Choirunisa, - and Anang Endaryanto, - and Soetjipto, - (2020) Procalcitonin and White Blood Cells as an Infection Marker in Children. J Indon Med Assoc, 70 (12). pp. 260-264. ISSN 26543796

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Abstract

Introduction: Diabetic ketoacidosis (DKA), an acute complication of type 1 (insulin dependent) diabetes mellitus (T1DM), can be precipitated by infection. Procalcitonin (PCT) is an accurate marker of bacteremia, sepsis, and inflammation, however white blood cells (WBC) are still often used by clinicians. We aimed to analyze PCT levels and WBC counts in children with DKA. Methods: A cross-sectional study was conducted in Dr. Soetomo General Hospital, Surabaya, Indonesia, between 2015 and 2019. T1DM and DKA diagnosis was based on the International Society for Pediatric and Adolescent Diabetes. PCT levels and WBC counts were measured in samples from patients with and without DKA, and were compared using the Mann-Whitney test. Results: A total of 41 samples were included, with 15 samples (36.6%) from children with DKA, and 26 (63.4%) from children without DKA. PCT levels and WBC counts were significantly higher in those with DKA (p<0.001). The receiver operating characteristic curve analysis of WBC was lower than PCT (0.849 vs. 0.982). PCT had a higher sensitivity and spesificity as an infection marker than WBC (93.3 vs. 86.7; 92.3 vs. 88.5, respectively). Conclusion: PCT is a better infection marker in children with DKA than WBC

Item Type:	Article
Uncontrolled Keywords:	type 1 diabetes mellitus, diabetic ketoacidosis, white blood cells, procalcitonin, biomarkers
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Divisions:	01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:	Creators NIM Nur Rochmah, - NIDN0029047909 Muhammad Faizi, - NIDN8890900016 Yudhi Kurniawan, dr., - NIM011181108 Latifatu Choirunisa, - UNSPECIFIED Anang Endaryanto, - NIDN8867700016 Soetjipto, - NIDN0017025004
Depositing User:	Mrs Elok Dian Nuraeni
Date Deposited:	25 Jun 2023 22:49
Last Modified:	25 Jun 2023 22:49
URI:	http://repository.unair.ac.id/id/eprint/127600
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• Procalcitonin and White Blood Cells as an Infection Marker in Children. (deposited 30 May 2023 22:06)
  • Procalcitonin and White Blood Cells as an Infection Marker in Children. (deposited 25 Jun 2023 22:49) [Currently Displayed]

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