Leonard Caesar Josediputra, Alexander and Aisiyah Widjaja, Nur and Irawan, Roedi (2022) Association of Adipoq +45 T>G Gene Polymorphism with Insulin Resistance and Icam-1 Value in Obese Adolescents. Indian Journal of Forensic Medicine & Toxicology, 16 (1). pp. 168-175. ISSN 0973-9122

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Abstract

Background: Obesity is defined as the accumulation of excess body fat tissue which harms health, such as cardiovascular disease, metabolic syndrome, diabetes mellitus type 2 and dyslipidemia. Lower adiponectin levels are strongly associated with overweight, obesity, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular risk factors in adulthood. ADIPOQ +45 T>G gene polymorphism is one of a genetic variations that affect plasma adiponectin levels. Methods: A cross-sectional study of 180 obese adolescents aged 13-18 years in Surabaya and Sidoarjo. Obesity is defined as body mass index (BMI)>p95 on the BMI for age curve according to Centers for Disease Control and Prevention (CDC) 2000. Blood samples were taken for ICAM-1 examination using the ELISA method, HOMA-IR with fasting insulin and glucose calculations, and ADIPOQ + 5 T>G gene polymorphisms by PCR-RFLP. Data were analyzed using the Chi-square, Mann-Whitney, and T-test using SPSS version 21, p-value<0.05 was considered significant. Results: There was a significant difference in the mean BMI by age group (p <0.001). There was no statistically significant difference between the median BMI in the three groups (wild, mutant homozygote, and mutant heterozygote) of genotype distributions. ADIPOQ +45 T>G gene polymorphisms occur with the same frequency in both males and females. There was no association between the genotype distribution of the ADIPOQ +45 T>G gene polymorphism with insulin resistance and ICAM-1 value, but the ICAM-1 value was found to be higher in the ≥ 15 years age group. There was no association between insulin resistance and ICAM-1 values. Conclusion: There was no association between ADIPOQ + 45 T>G gene polymorphisms with insulin resistance and ICAM-1 values in obese adolescents. There was no association between insulin resistance and ICAM-1 values.

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