Nur Aisiyah Widjaja, Nur and Roedi Irawan, - and Meta Herdiana Hanindita, - and IDG Ugrasena, - and Retno Handajani, - (2023) METS-IR vs. HOMA-AD and Metabolic Syndrome in Obese Adolescents. Journal of Medical Investigation, 70. pp. 2117-2121. ISSN 1343-1420

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Abstract

Abstract Purpose : Obesity is associated with chronic low-grade inflammation in which is the key in the pathogenesis Insulin Resistance (IR) and Metabolic Syndrome (MetS). Homeostasis model assessment of insulin resistance (HOMA-IR) has been validated as a surrogate measure of IR. The combination of HOMA and adiponectin, known as HOMA-AD was proposed to measure IR in adults. However, study on these indicators in obese adolescents is still limited. This study aims to analyse METS-IR and HOMA-AD to determine MetS and IR in obese adolescents. Methods : A cross-sectional study was conducted on obese adolescents who looked healthy from secondary schools in Surabaya and Sidoarjo, East Java, aged 12-18 years. Subjects were selected randomly and grouped into 2, namely MetS and non-MetS based on IDF 2000. Anthropometric examination and blood measurements, such as fasting blood glucose levels, lipid profiles, insulin, and adiponectin level were carried out according to standards. HOMA-IR, HOMA-AD, AND METS-IR were calculated using formula. Spearman’s Rho correlation were conducted between assessment tools (METS-IR and HOMA-AD) to identify the correlation with MetS component (lipid profile, FBG, and blood pressures). A receiving operation curve (ROC) performed to find area under curve (AUC) and cut-off points based on the biggest Youden index. Result : A total of 250 subjects were enrolled the study, and found 103 subjects had MetS. METS-IR correlates with all lipid profile and blood pressures (p?<?0.05). While HOMA-AD correlated with TG (r?=?0.356, p?=?0.000), systolic-BP (r?=?0.188, p?=?0.003), and HDL-c levels (r=-0.249, p?=?0.000). Cut-off point for METS-IR to determines MetS in obese adolescents was???46.53 (sensitivity of 64.24% and specificity of 75.76%), while HOMA-AD was???0.43 (sensitivity of 71.52% and specificity of 59.60%). Cut-off point for METS-IR index to determines IR was???52.01 (sensitivity of 83.44% and specificity of 44.44%). Cut-off point for HOMA-AD to determine IR was???0.37 (sensitivity of 74.17% and specificity of 84.85%). Conclusion : METS-IR is better surrogate to determine MetS with cut-off point of???46.53, while HOMA-AD is better to determine IR with cut-off point???0.37 in obese adolescents. J. Med. Invest. 70 : 7-16, February, 2023

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:	Creators NIM Nur Aisiyah Widjaja, Nur NIDN8935700020 Roedi Irawan, - UNSPECIFIED Meta Herdiana Hanindita, - UNSPECIFIED IDG Ugrasena, - UNSPECIFIED Retno Handajani, - UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	24 Oct 2023 01:25
Last Modified:	24 Oct 2023 01:25
URI:	http://repository.unair.ac.id/id/eprint/128481
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