Tamima Izzat Nabella, - (2024) Hubungan DMF-T/def-t Dengan Sekresi Hbd-1 Saliva Pada Kelompok Anak Berkaries Dan Bebas Karies. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: DMF-T / def-t (Decay Missing Filled Teeth) is an index for assessing dental and oral health status in this case dental caries. Dental caries is a multifactorial disease with factors such as teeth and saliva, microorganisms, food, and time that affect each other. Human Beta-Defensins-1 (HBDs) is an AMP, Antimicrobial peptides (AMPs) as an adaptive immune system in oral health is a factor that affects the susceptibility and development of dental caries that exhibits activity in mutant Streptococcus bacteria. Objective: To prove the DMF-T / deft relationship with levels ofHBD-1 saliva secretion in carious and caries-free children groups. Method: The type of this research is obeservasional analitik with cross sectional study design, with the division of 3 groups namely; group 1 (DMF-T / def-t = 0, caries-free), group 2 (DMF-T / deft = 1-3, low caries), group 3 (DMF-T / def-t> 6, caries high).Result: DMF-T / de_ft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T I deft index has high HBD-1 concentration, whereas high DMF-T I deft index has low HBD-1 concentration. The value ofp <(0.05) correlated significantly between the DMF-T I def-t index with salivary HBD-1 concentrations. Conclusions: There was a DMF-T I de_ft relationship with the level of HBD-1 saliva secretion in the carious and free caries group caries.

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