Eko Agus Subagio, Eko and Pandu Wicaksono, Pandu and Muhammad Faris, Faris and Abdul Hafid Bajamal, Abdul and Diaz Syafrie Abdillah, Diaz (2023) Diagnosis of Prevalence (1975-2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review. The Scientific World Journal, 2023 (667548). pp. 1-6. ISSN 2356-6140

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Abstract

Rheumatoid arthritis (RA), a chronic in/ammatory disease primarily a0ecting synovial joints and tendons, can potentially impact various organs within the body. One notable complication associated with RA is upper cervical spine instability, medically termed atlantoaxial subluxation (AAS). )is condition can lead to adverse consequences, including chronic myelopathy and acute mechanical compression of the medulla oblongata, with the potential for sudden death. While AAS may often remain asymptomatic, some nonspeci6c symptoms, such as neck pain, have been documented. Severe atlantoaxial subluxation can trigger more distinct symptoms, including delayed occipital pain attributed to the compression of the exiting C2 nerve root. Recent studies have elucidated a spectrum of symptoms preceding sudden death, encompassing vertigo, dizziness, convulsions, dysphagia, disorientation, and seizures. Remarkably, some cases have reported sudden death occurring during sleep. Historical data reveal a /uctuating incidence of this phenomenon, with eleven cases reported between 1969 and 1975 and six cases documented between 1990 and 2010. Notably, one of the most prevalent causes of sudden mortality in individuals with RA is the acute mechanical damage in/icted upon the medulla oblongata due to atlantoaxial subluxation.

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