Muhamad Robi'ul Fuadi, - and Jusak Nugraha, - and Hartono Kahar, - and Aryati, - (2023) Correlation Between Apolipoprotein E and Recurrent Acute Coronary Syndrome. Iranian Heart Journal, 24 (4). pp. 63-69. ISSN 1735-7306

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Abstract

Background: Heart disease manifestation due to plaque disruption in the coronary arteries is acute coronary syndrome (ACS). Apolipoprotein-E (Apo-E) is a multifunctional protein with central roles in lipid transportation and metabolism. We analyzed the correlation between the Apo-E blood concentration and recurrent ACS. Methods: This cross-sectional study recruited 90 patients who visited the outpatient cardiology clinic at Airlangga University Hospital. The patients were divided into 3 groups: without ACS, single ACS, and recurrent ACS. The Apo-E blood concentration was measured using the enzyme-linked immunosorbent assay in the Tropical Disease Center of the Airlangga University Laboratory. Results: The median Apo-E concentration was 3.6 (1.32-14.9) μg/mL in the recurrent ACS group, 4.01 (2.61-18.54) μg/mL in the single ACS group, and 3.95 (1.19-43.51) μg/mL in the group without ACS. The Kruskal-Wallis test showed no differences in Apo-E between the groups. The χ2 test demonstrated no correlation concerning Apo-E between the single ACS and recurrent ACS groups. The Fisher exact analysis showed no correlation between the Apo-E concentration and dyslipidemia. Conclusions: Our results showed no correlation between the Apo-E concentration and recurrent ACS.

Item Type:	Article
Uncontrolled Keywords:	Cardiovascular disease, Risk factor, Dyslipidemia, Apo-E
Subjects:	L Education > L Education (General) > L7-991 Education (General)
Divisions:	01. Fakultas Kedokteran > Patologi Klinik
Creators:	Creators NIM Muhamad Robi'ul Fuadi, - UNSPECIFIED Jusak Nugraha, - NIDN0014025602 Hartono Kahar, - UNSPECIFIED Aryati, - UNSPECIFIED
Depositing User:	HEMAS FAATIHAH
Date Deposited:	19 Jun 2024 00:11
Last Modified:	19 Jun 2024 02:05
URI:	http://repository.unair.ac.id/id/eprint/133386
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