Sri Agus Sudjarwo, - and Koerniasari, - and Masatoshi Hori, - and Hiroshi Ozaki, - (2009) SIGNAL TRANSDUCTION OF CURCUMIN FOR PROTECTION OF ENDOTHELIAL CELL IN HYPERCHOLESTEROLEMIA. Other thesis, UNIVERSITAS AIRLANGGA.

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Abstract

"Mechanism of curcumin for protection of endothelial cell was studied in cholesterolfed rabbits. Thirty rabbits were randomly divided into five groups_ The negative control group was fed a standard diet, the positive controi group was fed the same diet with 2 % cholesterol , the curcumin group was fed the same diet with 2 % cholesterol and curcumin 100 mglKg BW/day, 200 mg/Kg BW/day or 400 mg/Kg BW/day. The cholesterol-rich diet significantly increased Malondialdehyde (MDA) in the aortic blood vessels, as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), inhibited endothelium-dependent vascular relaxations to acetylcholine and decrease cyciic GMP were compared with vessels from normal rabbits (negative control). In cholesterol-fed rabbits, curcumin treatment decreased MDA in plasma production, improved endothelium - dependent relaxations to acetylcholine and increase cyclic GMP production. These results suggest that dietary treatment of rabbits with curcumin may prevent superoxide anion (d-) induced inactivation of endotheliumdependent relaxing factor (EDRF), improve the endothelium-dependent relaxation to acetylcholine in the aortic blood vessels and increase cyciic GMP content in aortic of cholesterol-fed rabbits."

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