Melanny Ika Sulistyowaty, - (2004) Studi Perbandingan Kinetika Peruraian Amoksisilin Dan N-Benzoilamoksisilin Dengan Penetapan Kadar Secara Kolorimetri. Skripsi thesis, UNIVERSITAS AIRLAGGA.

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Abstract

This research was done to compare stability of amoxicillin and its new derivate, N-benzoylamoxicillin. N-benzoylamoxicillin has great potency to be developed furthermore because it’s more active against Pseudomonas aeruginosa and Staphylococcus aureus. The stability was determined by studying degradation kinetics of these compounds at various temperatures (40°C, 50°C, 60°C and 70°C) and times (30, 60, 90, 120, and 150 minutes). The parameters which can be obtained from this research are rate constant of reaction (k), half-life (t½) and activation energy (Ea). The degradation of these compounds was determined by colorimetric method. The principle of this method is simple and specific for compound with β-lactam ring. Hydroxylamine will break β-lactam ring of amoxicillin and N-benzoylamoxicillin, and with addition of ferric ion will form chromatic complex. The colored-complex’s absorbance can be analyzed quantitatively by Spectrophotometer UV-Vis. Curve plots between log Ct/Co and time which is obtained at various temperatures and times were linier, indicating that the degradation of amoxicillin and N-benzoylamoxicillin follows first-order kinetics. The value of physical chemistry’s parameters of stability obtained from research shows that amoxicillin as the lead compound is more stable than N-benzoylamoxicillin. Calculation Q10 of these compounds shows that N-benzoylamoxicillin is more stable to hold up elevated the temperature than amoxicillin. Based on this research, it’s expected that the next research can be developed furthermore to determine N-benzoylamoxicillin’s potency and to increase the stability.

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