Ajeng Erika Prihastuti Haskito, ,- (2013) Aktivitas Vitamin E (a-Tocopherol) Sebagai Antioksidan Pada Histopatologi Dan Kadar Malondialdehyde (MDA) Hati Mencit Galur BALB/C Yang Dipapar 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD): Penelitian Eksperimental Laboratoris. Thesis thesis, UNIVERSITAS AIRLANGGA.

Text (Fulltext) 166. AKTIVITAS VITAMIN E (a-TOCOPHEROL) SEBAGAI ANTIOKSIDAN - AJENG ERIKA PRIHASTUTI HASKITO - TIDAK ADA.pdf Download (3MB)

Abstract

The aim of this research was to observe the activity of vitamin E (atocopherol), which is well known to have potential as an antioxidant, to protect the damage of the body post exposure to 2,3,1,8-tetrachlorodibenzo-p-dioxin (TCDD). A total of thirty male Balb/c mices of l 0 weeks old were used in this research. The mices were divided into five groups: ( l) as a negative control group was given com oil, (2) Group 0 was given TCDD with dose I 00 nglkg body weight/day/head and com oil, (3) Group l was given TCDD with dose 100 nglkg body weight/day/head and vitamin E (a-tocopherol) with dose 11 mg/kg body weight/day/head., (4) Group 2 was given TCDD with dose 100 nglkg body weight/day/head and given vitamin E (a-tocopherol) with dose 20 mg/kg body weight/day/head, (5) Group 3 was given TCDD with dose 100 nglkg body weight/day/head and given vitamin E (atocopherol) with dose 37 mg/kg body weight/day/head. Provision of TCDD and vitamin E (a-tocopherol) is done for thirty-five days with per-oral. After thirty-five days of treatment, the liver sample were collected for histophatological examination and Malondialdehyde (MDA) analyzed. Experimental method was based on completely randomized design. The histopathological were analyzed by KruskallWallis test followed by Mann-Whitney test to know the differences of the treatments, while the MDA data were analyzed by ANOVA test followed by Duncan test. The result of the research showed that the vitamin E ( a-tocopherol) could protect the mice liver from damage post exposure to TCDD.

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