Tutus Rachkutho, - (2022) Hubungan Antara Kejadian Dislipidemia Dengan Proteinuria Pada Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Inap Bagian Medik Rsud Dr. Soetomo Periode Januari 2019 – Januari 2020. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Lipid profile abnormalities are often found in people with diabetes mellitus. Diabetes mellitus patients, especially type 2, have hyperglycemia levels that are related to insulin resistance to facilitate hyperlipidemia which has an important role in the formation of atherosclerosis which causes narrowing of the blood vessel lumen and decreases blood flow velocity which causes reduced blood supply to the kidneys. In addition, hyperglycemic conditions can increase the permeability of blood vessels in the kidneys causing proteinuria through increased activation of protein kinase c enzymes and production of vasoactive hormone angiotensin II. Dyslipidemia caused by hyperglycemic conditions activates reactive oxygen species (ROS) that have an important role in podocyte apoptosis, increasing macrophage infiltration and excessive extracellular matrix production in glomeruli in diabetic conditions, contributing to the development of chronic kidney disease (CKD). One of the complications of diabetes mellitus is diabetic nephropathy which is indicated by proteinuria. The aim of the study is to determine the relationship between lipid profile and the occurrence of proteinuria in patients with type 2 diabetes. This research used retrospection with a cross sectional approach. The subjects in this study amounted to 61 patients with type 2 diabetes mellitus with dyslipidemia in RSUD Dr. Soetomo in January 2019-January 2020 with medical record. Dependent variable were lipid profile and proteinuria. Results: The results of spearman tests showed that there was a significant relationship between HDL dyslipidemia with proteinuria levels in patients with type 2 diabetes mellitus (p=0.043, rs=0,260). Conclusion: There is a significant relationship between HDL dsylipidemia with proteinuria levels in patients with type 2 diabetes mellitus. Keywords: Diabetes Mellitus 2, Dyslipidemia, Nephropathy, Proteinuria

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