Setiawati, Yuani and Kurnijasanti, Rochmah and D' Arqom, Annette and Nugraha, Jusak and Illiandri, Oski and Sudjarwo, Sri Agus (2026) The Protective Effect of Amorphophallus oncophyllus against Indomethacin-Induced Duodenal Mucosal Injury in Rats via Inhibition of Inflammatory Cell Infiltration. Borneo Journal of Pharmacy, 8 (4). 388 - 397.

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause significant gastrointestinal mucosal injury, particularly in the duodenum. This damage is often initiated by localized erosion of the duodenal mucosa, which triggers a subsequent inflammatory cascade. The porang tuber (Amorphophallus oncophyllus) is a promising candidate for mitigating this injury due to its rich composition of bioactive compounds, including flavonoids, alkaloids, tannins, and glucomannan, all of which possess known anti-inflammatory properties. This study investigated the protective effect of an ethanolic A. oncophyllus extract on the duodenal mucosa in an indomethacin-induced rat model. Thirty Wistar white rats (Rattus norvegicus) were randomly assigned to five groups: a vehicle control, a model group receiving indomethacin, and three treatment groups that were pretreated with A. oncophyllus extract at doses of 50, 100, and 200 mg/kg, respectively, for seven days before a single dose of indomethacin. Our findings demonstrated that the A. oncophyllus extract, particularly at a dose of 200 mg/kg, effectively reduced duodenal mucosal injury caused by indomethacin. This protective effect is likely attributable to the extract�s phytochemical profile, which contains flavonoids, tannins, saponins, terpenoids, and alkaloids. In conclusion, this research confirms that A. oncophyllus extract has the potential to protect the duodenal mucosa from NSAID-induced damage. © 2025 Yuani Setiawati, Rochmah Kurnijasanti, Annette D�Arqom, Jusak Nugraha, Oski Illiandri, Sri Agus Sudjarwo.

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