WAHIDUDDIN (2019) POLIMORFISME FOK 1 GEN RESEPTOR VITAMIN D DAN STATUS VITAMIN D PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN TUBERKULOSIS PARU. Disertasi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Background: Vitamin D plays a role in support ing macrophage activation via vitamin D receptor. Polymorphi sm of Fokl, vitamin D receptor gene, can show the different level of susceptibi lity to pulmonary tuberculosis (PTB). Objective: This research aimed to elucidate the polymorphism of vitamin 0 receptor gene and vitamin D concentration in type 2 diabetes mellitus (T2DM) patients with PTB. Methods: A case-control study was carried out on T2DM adult patients who took the medication in endocrine, internal medicine, and pulmonary clinics of two governmental hospitals in Surabaya city. The samples consisted of 45 patients each ofT2DM with and without PTB. PCR, RFLP, and DNA sequencing were used to test Fok1 polymorphism. The concentration of plasma vitamin D (25-0H) was measw-ed using ELISA DBC Diagnostic Biochem. Results: The group ofT2DM with PTB indicated allele frequency ofF (63.3%) and f (36.7%) and genotype di stribution of FF (40%), Ff (46.7%), and ff (13.3%). The group ofT2DM without PTB showed F (54.8%) and f(45.2%) allele and FF (33.3%), Ff(46.7%), and ff(20.0%) genotype. Median of plasma vitamin D concentration was 20.26 ng/ml showing deficiency (37.9%) and insuffi ciency (62.1 %) categories in the group ofT2DM with PTB. The higher risk of vitamin D deficiency was found on the patients age > 50 years, female, and body mass index (BMI) 2:: 25.0 kg/m2 Conclusion: There was no difference in allele frequency, genotype distribution of Fokl gene polymorphism, and vitamin D concentration between T2DM patients with and without PTB. Nevertheless. FF genotype with insufficient vitamin D concentration indicated a significant association to PTB development on T2DM patients.
| Item Type: | Thesis (Disertasi) | |||||||||
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| Uncontrolled Keywords: | Fok I polymorphism, vitamin D receptor gene, vitamin D status, type 2 diabetes mellitus, pulmonary tuberculosis, PCR-RFLP, DNA sequencmg | |||||||||
| Subjects: | R Medicine | |||||||||
| Divisions: | 01. Fakultas Kedokteran > S3 Ilmu Kedokteran | |||||||||
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| Depositing User: | Dwi Marina | |||||||||
| Date Deposited: | 28 Aug 2026 06:49 | |||||||||
| Last Modified: | 28 Aug 2026 06:49 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/145199 | |||||||||
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