CLARRISA FREDLINE, 020911136 (2013) PENGARUH IRAMA SIRKADIAN TERHADAP JUMLAH OSTEOBLAS TULANG ALVEOLAR MARMUT (Cavia cobaya)PASCA PEMASANGAN SEPARATOR. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Light is one of the most important external stimulus in circadian rhythm. The light-dark cycle in environment could affect the secretion of melatonin from the pineal gland. Change of melatonin secretion could affect bone remodelling by increasing osteoblast counts. Purpose: The aim of this study is to find the effect of circadian rhythm in osteoblast counts in alveolar bone.Methods:Marmots (Cavia cobaya) were classified into three groups: control group (12 Hours Light:12 Hours Dark/12HL:12HD), constant light/24 Hours Light (24HL) group and constant dark/24 Hours Dark (24HD) group.Marmots are given light-dark stimulus for 15 days. Later on, tooth separator were inserted in the marmots’ upper teeth together with light-dark stimulus for 7 days. Osteoblast count was measured after staining with Mason Trichrome.Results: There is only inactive osteoblast and there is no significant difference between each group(p>0,05). Conclusion: Circadian rhythm doesn’t haveeffect in osteoblast counts in alveolar bone. Keywords: Circadian rhythm, melatonin,osteoblast counts

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